Fructosamine Calculation Formula

Fructosamine Equation:

\[ \text{Fructosamine (µmol/L)} = (\text{HbA1c (\%)} - 1.61) \times 58.82 \]

Fructosamine:

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1. What is the Fructosamine Calculation Formula?

The Fructosamine Calculation Formula estimates fructosamine levels from HbA1c values. Fructosamine provides an indication of average blood glucose levels over the past 2-3 weeks, complementing the longer-term view provided by HbA1c.

2. How Does the Calculator Work?

The calculator uses the Fructosamine equation:

\[ \text{Fructosamine (µmol/L)} = (\text{HbA1c (\%)} - 1.61) \times 58.82 \]

Where:

\( \text{HbA1c} \) — Glycated hemoglobin percentage
1.61 — Constant adjustment factor
58.82 — Conversion multiplier

Explanation: This formula provides a mathematical conversion between HbA1c percentage and fructosamine levels measured in micromoles per liter.

3. Importance of Fructosamine Calculation

Details: Fructosamine measurement is particularly useful for monitoring short-term glycemic control, especially in situations where HbA1c may be unreliable or when recent changes in diabetes treatment need assessment.

4. Using the Calculator

Tips: Enter HbA1c value as a percentage. The value must be valid (greater than 0). The calculator will provide the corresponding fructosamine level in µmol/L.

5. Frequently Asked Questions (FAQ)

Q1: What is the clinical significance of fructosamine?
A: Fructosamine reflects average blood glucose levels over the preceding 2-3 weeks, making it useful for monitoring recent glycemic control and treatment adjustments.

Q2: When is fructosamine preferred over HbA1c?
A: Fructosamine is particularly valuable in conditions where HbA1c may be unreliable, such as hemoglobinopathies, anemia, pregnancy, or recent blood transfusions.

Q3: What are normal fructosamine values?
A: Normal fructosamine levels typically range between 200-285 µmol/L, though reference ranges may vary slightly between laboratories.

Q4: How does fructosamine correlate with average glucose?
A: Fructosamine levels correlate well with mean blood glucose levels over the preceding 2-3 weeks, providing a shorter-term glycemic assessment than HbA1c.

Q5: Are there limitations to this conversion formula?
A: While this formula provides a useful estimate, individual variations in protein glycation rates may affect the accuracy of the conversion in specific cases.